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Pathways
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PATHWAY ONTOLOGY - ANNOTATIONS

The Pathway Ontology (PW), is currently being developed at the Rat Genome Database. For more information about this vocabulary, please see Petri et al. The rat genome database pathway portal. Database (Oxford). 2011 Apr 8;2011:bar010. Print 2011 or contact us (http://rgd.mcw.edu/contact/index.shtml).
Term:heparin pharmacodynamics pathway
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Accession:PW:0002329 term browser browse the term
Definition:The pathway of heparin-target interaction and of the biochemical or physiological responses to drug. Heparin is a naturally occurring anticoagulant that binds to and activates the thrombin inhibitor antithrombin III (AT). Genetic variations can cause differences in the response of the organism to the drug.
Synonyms:related_synonym: SMP:00274

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heparin pharmacodynamics pathway term browser
Symbol Object Name Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G COL1A1 collagen type I alpha 1 chain ISO SMPDB SMP:00274 NCBI chr16:43,134,648...43,152,313
Ensembl chr16:43,134,779...43,150,930 		JBrowse link
G F10 coagulation factor X ISO SMPDB SMP:00274 NCBI chr 3:91,125,097...91,154,000
Ensembl chr 3:91,124,766...91,157,376 		JBrowse link
G F11 coagulation factor XI ISO SMPDB SMP:00274 NCBI chr 7:132,180,026...132,207,081
Ensembl chr 7:132,180,336...132,208,155 		JBrowse link
G F12 coagulation factor XII ISO SMPDB SMP:00274 NCBI chr23:79,414,074...79,438,896
Ensembl chr23:79,414,225...79,432,298 		JBrowse link
G F13A1 coagulation factor XIII A chain ISO SMPDB SMP:00274 NCBI chr17:65,885,498...66,040,026
Ensembl chr17:65,885,658...66,040,040 		JBrowse link
G F13B coagulation factor XIII B chain ISO SMPDB SMP:00274 NCBI chr25:32,357,540...32,390,349
Ensembl chr25:32,357,993...32,389,973 		JBrowse link
G F3 coagulation factor III, tissue factor ISO SMPDB SMP:00274 NCBI chr20:38,726,690...38,738,457
Ensembl chr20:38,726,798...38,739,408 		JBrowse link
G F5 coagulation factor V ISO SMPDB SMP:00274 NCBI chr25:59,465,610...59,539,022
Ensembl chr25:59,466,378...59,538,872 		JBrowse link
G F7 coagulation factor VII ISO SMPDB SMP:00274 NCBI chr 3:91,109,864...91,122,707
Ensembl chr 3:91,110,380...91,123,327 		JBrowse link
G F8 coagulation factor VIII ISO SMPDB SMP:00274 NCBI chr  X:129,090,140...129,315,343
Ensembl chr  X:129,088,611...129,312,909 		JBrowse link
G F9 coagulation factor IX ISO SMPDB SMP:00274 NCBI chr  X:114,618,397...114,650,827
Ensembl chr  X:114,618,639...114,651,365 		JBrowse link
G FGA fibrinogen alpha chain ISO SMPDB SMP:00274 NCBI chr 7:101,127,554...101,134,881
Ensembl chr 7:101,125,791...101,134,405 		JBrowse link
G FGB fibrinogen beta chain ISO SMPDB SMP:00274 NCBI chr 7:101,106,468...101,114,566
Ensembl chr 7:101,106,483...101,114,662 		JBrowse link
G FGG fibrinogen gamma chain ISO SMPDB SMP:00274 NCBI chr 7:101,148,457...101,157,245
Ensembl chr 7:101,148,058...101,157,111 		JBrowse link
G GGCX gamma-glutamyl carboxylase ISO SMPDB SMP:00274 NCBI chr14:21,593,202...21,605,800
Ensembl chr14:21,593,088...21,604,885 		JBrowse link
G KLKB1 kallikrein B1 ISO SMPDB SMP:00274 NCBI chr 7:132,143,514...132,173,189
Ensembl chr 7:132,144,420...132,173,187 		JBrowse link
G PLAT plasminogen activator, tissue type ISO SMPDB SMP:00274 NCBI chr 8:40,164,391...40,196,627
Ensembl chr 8:40,163,891...40,196,555 		JBrowse link
G PLG plasminogen ISO SMPDB SMP:00274 NCBI chr13:88,266,054...88,321,596
Ensembl chr13:88,268,198...88,322,644 		JBrowse link
G SERPINC1 serpin family C member 1 ISO SMPDB SMP:00274 NCBI chr25:55,271,823...55,289,855 JBrowse link
G VKORC1 vitamin K epoxide reductase complex subunit 1 ISO SMPDB SMP:00274 NCBI chr 5:27,778,553...27,782,639
Ensembl chr 5:27,776,416...27,782,640 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  pathway 4034
    drug pathway 383
      blood and blood forming organs drug pathway 59
        antithrombotic drug pathway 59
          anticoagulant drug pathway 27
            heparin group drug pathway 20
              heparin drug pathway 20
                heparin pharmacodynamics pathway 20
paths to the root